Custom Peptides
Cayman Chemical Fructose1 6bIsphosphatse1 10mg
A cell-permeable benzoxazolo-sulfonamide compound that blocks human FBPase-1 enzymatic activity by competing at the AMP allosteric binding site (IC50 = 3.4 µM; Ki = 1.1 µM); blocks glucose production in starved rat hepatoma cells (IC50 = 6.6 µM)
Cayman Chemical nrvonyl EthnolamIde 10mg
A member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids
Cayman Chemical SardomozIdehydrochlorIde 10mg
An inhibitor of SAMDC (IC50 = 0.005 µM for the rat liver enzyme); selective for SAMDC over DAO (IC50 = 18 µM for the rat small intestine enzyme); inhibits proliferation of T24 cells (IC50 = 0.71 µM); decreases intracellular levels of spermidine and spermine and increases intracellular putrescine levels in L1210 cells at 3 µM; inhibits HIV-1 replication in PM1 cells at 0.2 and 0.4 µM; reduces tumor growth in a SK-MEL-24 melanoma mouse xenograft model at 0.5 and 5 mg/kg
Cayman Chemical SafInamIde AcId 10mg
A potential impurity found in commercial preparations of safinamide; a degradation product formed under conditions of thermal and oxidative stress
Cayman Chemical Tafenoqun 10mg
An antimalarial agent; active against multidrug-resistant clinical isolates of P. falciparum (IC50s = 64.6-110.4 ng/ml); inhibits sporozoite transmission to mosquitos fed on P. berghei-infected mice at 25 or 50 mg/kg; suppresses parasitemia in a hamster model of B. microti infection from 3.25-52 mg/kg
Cayman Chemical AWD 131-138 10mg
A partial agonist of the GABAA receptor that acts at the benzodiazepine binding site, dose-dependently stimulating GABA currents with a threshold of 0.3-1.0 µM; displays a broad spectrum of anticonvulsant activity in diverse seizure and epilepsy models without a tendency toward tolerance or abuse
Cayman Chemical JacarIc AcId 10mg
A conjugated PUFA that induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 µM); increases the production of ROS, leading to oxidative stress that contributes to cytotoxicity
Cayman Chemical MIlnacIprnhydrochlorIde 10mg
A serotonin and norepinephrine reuptake inhibitor; selectively inhibits the human serotonin transporter and norepinephrine transporter over the dopamine transporter (IC50s = 420, 77, and 6,100 nM, respectively); inhibits sodium-dependent serotonin and norepinephrine uptake over dopamine uptake in rat cerebral cortical synaptosomes (IC50s = 28.0, 29.6, and >10,000 nM, respectively); is an antagonist of the 5-HT3A and nAChRs (IC50s = 63.5 and 14.3 μM, respectively); increases withdrawal threshold and latency in response to tactile and heat stimulation, respectively, in nerve-ligated mice (30 mg/kg)
Cayman Chemical EstramustIn PhosphATsodIu 10mg
A derivative of estradiol that destabilizes microtubules (Kds = 10 and 15 µM for MAP-1 and MAP-2, respectively); induces cell cycle arrest in mitosis at the metaphase stage in DU145 and PC3 prostate cancer cells; induces apoptosis in U87MG human malignant glioma cells
Cayman Chemical TIn MSoporphyrIn IXCLOrId 10mg
A potent, competitive inhibitor of HO activity in vitro (Ki = 14 nM); inhibits hepatic, renal, and splenic HO activity in vivo for extended periods of time; blocks bilirubin production in vivo, decreasing HO activity in animal models of hyperbilirubinemia
Cayman Chemical Ajmalcn 10mg
A terpenoid indole alkaloid; an α1-AR antagonist that reduces the phenylephrine-induced pressor response in pithed rats at 1-4 mg/kg; binds to α2A-, α2B-, α2C-, and α2D-ARs (Kis = 8.2, 14.5, 5, and 289 nM, respectively); improves hemodynamic and metabolic parameters following transient cerebral ischemia in dogs when used in combination with almitrine
Cayman Chemical Falurdn 10mg
A nucleoside analog with antiviral activity, inhibiting thymidine kinases from herpes simplex virus types 1 and 2 with Ki values of 0.14 and 0.95 µM, while blocking green monkey Vero cell thymidine kinase less effectively (Ki = 53 µM)
Cayman Chemical PImecrolImus 10mg
A macrolactam that binds to macrophilin-12 and inhibits calcineurin as well as prolyl isomerase; the activation of T cells by allogeneic dendritic cells (IC50 = 0.55 nM) and suppresses the generation of pro-inflammatory cytokines; used in countering inflammatory skin diseases, such as eczema and psoriasis