Custom Peptides
Cayman Chemical 11-deoxy ProstaglndIn F2a 10mg
11-deoxy PGF2α is a synthetic analog of PGF2α. It is a more potent agonist than PGF2α at inducing smooth muscle contractions of rabbit aorta, dog saphenous vein, and guinea pig trachea.{2260} It is approximately 20% less potent than U-46619.{2260}
Cayman Chemical 3Methylbuphedronhydrochlo 10mg
A methylated analog of buphedrone; intended for forensic and research applications
Cayman Chemical 4-O-methyl QuercetIn 10mg
A flavonoid from C. ordata with anticancer and antiplasmodial activity; inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM; induces G2-M arrest and inhibits tubulin polymerization in vitro; inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 0.040 μM in a vesicular transport assay); reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM)
Cayman Chemical TaurolIthocholIc AcIdodIM 10mg
A taurine-conjugated form of lithocholic acid; increases caspase-3 and -7 activity in NTCP-transfected Hep3B cells at 75 µM; has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis; serum levels of TLCA increase approximately 5-fold in within two hours during an oral lipid tolerance test in humans
Cayman Chemical CrostIdetrIfluoroacetAT s 10mg
A peptide substrate for Akt; corresponds to the amino acid sequence of GSK3 that surrounds the serine residue phosphorylated by RSK1 or p70S6K; also a substrate for SGK3
Revvity Health Sciences Inc AlphaLISA Human LC3B Detection Kit, Standard
AlphaLISA Human LC3B Detection Kit, Standard
Cayman Chemical ML-133hydrochlorIde 10mg
A Kir2 channel inhibitor (IC50s = 1.8, 2.8, 2,9, and 2.6 µM for Kir2.1, Kir2.2, Kir2.3, and Kir2.6, respectively); selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC50s = 33 and 76 µM, respectively); prevents the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury at 10 and 30 nmol/animal
Cayman Chemical ForodesInhydrochlorIde 10mg
A nucleoside derivative and PNP inhibitor (IC50s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively); inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human PBLs in the presence of 2'-deoxyguanosine; inhibits the proliferation of CEM-SS T-ALL; prolongs survival in the hu-PBL-SCID mouse model of xenogeneic GVHD
Cayman Chemical Mahanimbine 10mg
A carbazole alkaloid; active against S. aureus and S. pyogenes (MIC100 = 50 UG/ml for both); induces cell cycle arrest at the G0/G1 phase and apoptosis in Capan-2 and SW1190 cancer cells at 7 µM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 µM, respectively); decreases body weight gain without affecting food intake and reduces increases in plasma total cholesterol and triglyceride levels in a rat model of high-fat diet-induced obesity at 30 mg/kg
Cayman Chemical RIsutegnIbtrIfluoroacetAT 10mg
An anti-integrin peptide; protects against hydroquinone-induced necrosis and apoptosis, as well as inhibits hydroquinone-induced production of ROS in RPE cells at 400 µM; decreases expression of BAX, VEGFA, and ITB1 in human AMD cybrid cell lines at 20 mg/ml; arrests aberrant blood vessel growth mediated by αVβ3, αVβ5, and α5β1 integrins in vivo
Cayman Chemical Taurolthocholc ACD 3sulfa 10mg
A metabolite of taurolithocholic acid; has been used to study bile acid transport in cellular models and to induce pancreatitis in mouse models of bile acid infusion pancreatitis
Cayman Chemical Carebastn 10mg
An active metabolite of ebastine and a histamine H1 receptor antagonist; inhibits histamine-induced contraction of isolated guinea pig trachea (IC50 = 120 nM); inhibits histamine release from isolated rat peritoneal mast cells and human basophils at 30-100 µM; decreases production of CCL5 and CCL2 in primary human nasal epithelial cells isolated from patients with nasal allergies
Cayman Chemical Amodaqun 10mg
A prodrug form of N-desethyl amodiaquine; active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine; dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection
Cayman Chemical -NorepInphrIn-d6hydroc 10mg
An internal standard for the quantification of norepinephrine by GC- or LC-MS
Cayman Chemical 1 4MethoxyphenylpIperazIn 10mg
A piperazine derivative assumed to have a mixed mechanism of action, with serotonergic and dopamine antagonistic properties in a similar fashion to 3,4-methylenedioxymethamphetamine; intended for research and forensic purposes